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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 405747생성일: 2026년 10월 25일

1-Cyanocyclopropanecarboxylic acid → 1-Cyano-cyclopropanecarboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

https://huagongshe.com/reaction/405747

반응식

참여 물질

역할이름HCID투입량
반응물1-Cyanocyclopropanecarboxylic acidHCID 2733259—
반응물(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672004—
생성물1-Cyano-cyclopropanecarboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amideHCID 66558857—

반응 단계

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 1-cyano-cyclopropanecarboxylic acid (CAS 6914-79-0) following procedure I yielded the title compound as a white foam. MS (ISP): m/z=335.3 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08754075B2
출처 데이터셋uspto-grants-2014_06
ORD IDord-ac7b2936dfa14fd085b9ad6e8852c757
출처 메모uspto-grants-2014_06