反应详情

A solution of piperazine-1-carboxylic acid tert-butyl ester (114 g) in DCM (500 mL) was cooled in an ice bath and treated with phenyl isocyanate (65 mL). After 1 hour (h), the bath was removed. After 15 h, the resulting mixture was filtered and the solid was washed with dichloromethane (DCM, 2×100 mL), giving the title compound as a white amorphous solid (95 g).

1. customthe bath was removed
2. waitAfter 15 h
3. filtrationthe resulting mixture was filtered
4. washthe solid was washed with dichloromethane (DCM, 2×100 mL)