참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Methoxyacetohydrazide | HCID 2759532 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | Ethyl 6-cyanoimidazo[1,2-a]pyridine-3-carboxylate | HCID 67259960 | — |
| 용매 | Glycol monoethyl ether | HCID 8076 | — |
| 생성물 | HCID 178494722 | HCID 178494722 | — |
반응 단계
To a solution of ethyl 6-cyanoimidazo[1,2-a]pyridine-3-carboxylate (24q) (265 mg, 1.23 mmol) and 2-methoxyacetohydrazide (193 mg, 1.85 mmol) in 2-ethoxyethanol (5 mL) was added NaOMe (0.5 M in MeOH, 3.7 mL). The mixture was heated at 110° C. in a sealed vial overnight. The reaction mixture was purified by HPLC to give 6-(3-(methoxymethyl)-1H-1,2,4-triazol-5-yl)imidazo[1,2-a]pyridine-3-carboxylic acid (99). MS m/z 274.1 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08754071B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_06 |
|---|
| ORD ID | ord-f1b603e8bf0a4b26b8f2b3612b923f53 |
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| 출처 메모 | uspto-grants-2014_06 |
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