HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzeneacetamide → (+/-)-Trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-phenyl-pyrrolidine-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzeneacetamide | HCID 7680 | — |
| Reactant | 2-(2-Chloro-4-fluorophenyl)acetamide | HCID 2773716 | — |
| Product | (+/-)-Trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-phenyl-pyrrolidine-2,5-dione | HCID 86608200 | — |
Reaction Steps
(±)-Trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-phenyl-pyrrolidine-2,5-dione was prepared according to the Example 40 replacing 2-chloro-4-fluorophenylacetamide with phenylacetamide. 1H NMR (DMSO-d6) 400 MHz δ: 11.511 (s, 1H), 7.24-7.36 (m, 6H), 7.13 (d, 1H, J=7.2), 6.8-6.88 (m, 2H), 4.49 (d, 1H, J=8.0 Hz), 4.3 (d, 1H, J=7.6 Hz), 4.08 (m, 2H), 2.88 (m, 2H), 2.088 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754078B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-dc744963df684660aee3dcbe6fd56546 |
| Source note | uspto-grants-2014_06 |