2-(2-chlorophenyl)acetamide → HCID 86608201, compound

HRID 405887Notes

Reaction equation

HRID 405887 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([NH2:12])=[O:11].Cl[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][C:21]([NH2:23])=O>>[C:20]1([C@H:9]2[C@H:9]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:10](=[O:11])[NH:12][C:10]2=[O:11])[C:15]2=[C:16]3[C:17](=[CH:18][CH:19]=[CH:14]2)[CH2:7][CH2:2][CH2:3][N:23]3[CH:21]=1

Participants

3

Reactant 2

HCID 6411412-(2-chlorophenyl)acetamideHCID 27737162-(2-Chloro-4-fluorophenyl)acetamide

Product 1

HCID 86608201HCID 86608201, compound

Procedure

(±)-Trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-(2-chlorophenyl)-pyrrolidine-2,5-dione was prepared according to Example 40 replacing 2-chloro-4-fluorophenylacetamide with 2-chlorophenylacetamide. 1H NMR (DMSO-d6) 400 MHz δ: 11.655 (s, 1H), 7.41-7.48 (m, 2H), 7.27-7.35 (m, 3H, J=7.2), 7.87 (d, 1H, J=7.6), 6.81-6.88 (m, 2H), 4.632 (d, 1H, J=7.6 Hz), 4.494 (d, 1H, J=7.2), 4.07-4.10 (m, 2H), 2.884 (m, 2H), 2.09 (m, 2H).

Sources & evidence

ORD record
ord-e8b8054a74594878bbc1a52cc3653a24
Source dataset
uspto-grants-2014_06
Patent number
US08754078B2

Reaction notes

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