HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 405908Generated: October 30, 2026
Water → (R)-1-amino-1-(4-fluorophenyl)-2-methylpropan-2-ol
https://huagongshe.com/reaction/405908
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 59708427 | HCID 59708427 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-1-amino-1-(4-fluorophenyl)-2-methylpropan-2-ol | HCID 59708392 | 87.1% |
Reaction Steps
5.6 g 2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide and 2.27 g KOH are suspended in 60 ml of methanol. The reaction mixture is stirred for 20 hours at 60° C., then mixed with water and the product is extracted with dichloromethane. 3.2 g product are obtained as an oil. Analytical HPLC-MS (method A): RT=0.79 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08754073B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-d13efd5b36354c858a66814ea7decfa6 |
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| Source note | uspto-grants-2014_06 |
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