2-ethyl-5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole → 2-ethyl-5-fluoro-3-piperidin-4-yl-1H-indole

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Reaction Steps

2.83 g 2-ethyl-5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole are suspended in 50 ml of methanol and hydrogenated with 0.3 g Pd/C 10% at normal pressure and ambient temperature. The catalyst is suction filtered and the filtrate is evaporated to dryness. 2.3 g (V-1) are obtained as a solid. 1H NMR (400 MHz, DMSO): 2.70 (2H, q); 1.19 (3H, t).

Provenance & Evidence