Ethanol → HCID 66863463, compound

HRID 405915Notes

Reaction equation

HRID 405915 reaction equation
[CH2:1]([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([C:23]([OH:25])=[O:24])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH2:31](O)[CH3:32]>>[CH2:1]([N:8]1[CH2:9][CH:10]=[C:11]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([C:23]([O:25][CH2:31][CH3:32])=[O:24])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 66669797HCID 66669797, compound

Product 1

HCID 66863463HCID 66863463, compound

Procedure

12.4 g 3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-6-carboxylic acid are suspended in 80 ml of ethanol and 1.6 ml conc. Sulphuric acid are added. The reaction mixture is stirred for 96 hours at reflux temperature. The solid is suction filtered, dissolved in ethanol and made basic with sodium hydroxide solution. 5.3 g product are obtained as a solid.

Workup

  1. temperatureat reflux temperature
  2. filtrationfiltered
  3. dissolutiondissolved in ethanol

Sources & evidence

ORD record
ord-af9dfe718fc34e6d9dbfe9e498e37425
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

Loading…