HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 405921Generated: October 28, 2026
Diisopropylethylamine → HCID 58080356, compound
https://huagongshe.com/reaction/405921
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 12433335 | HCID 12433335 | — |
| Reactant | 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine | HCID 45789967 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58080356 | HCID 58080356 | — |
Reaction Steps
2.7 g (II) are placed in 30 ml dioxane, then 6.8 ml diisopropyl-ethylamine and 1.8 g 2-(1-aminocyclopropyl)-propan-2-ol (see Liebigs Ann. Chem. 1978.1194) are added. The reaction mixture is heated to 160° C., until there is no further reaction, and after cooling evaporated to dryness. The residue is combined with ice water. The product is extracted with dichloromethane and purified by chromatography. 125 mg (III-8) are obtained as a solid. Analytical HPLC-MS (method A): RT=1.08 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08754073B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-d8f57d4d709b482082dab0e88b2aa341 |
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| Source note | uspto-grants-2014_06 |
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