反应详情

500 mg 2-amino-4-fluorophenol and 900 mg mono-tert-butyl piperidine-1,4-dicarboxylate are heated in 5 g polyphosphoric acid at 200° C. for 4 h. After cooling the reaction mixture is combined with ice water and made basic with 50% NaOH solution. The precipitate is suction filtered, washed with water and dried. 290 mg (V-8) are obtained as a solid.

1. temperatureAfter cooling the reaction mixture
2. filtrationfiltered
3. washwashed with water
4. customdried
5. custom290 mg (V-8) are obtained as a solid