Sodium Hydroxide → HCID 18365331, compound

HRID 405924Notes

Reaction equation

HRID 405924 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[N:10]1(C(OC(C)(C)C)=O)[CH2:15][CH2:14][CH:13]([C:16]([O-])=O)[CH2:12][CH2:11]1.[OH-].[Na+]>>[F:8][C:6]1[CH:5]=[CH:4][C:3]2[O:9][C:16]([CH:13]3[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]3)=[N:1][C:2]=2[CH:7]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 27359172-Amino-4-fluorophenolHCID 6921829HCID 6921829, compound

Product 1

HCID 18365331HCID 18365331, compound

Procedure

500 mg 2-amino-4-fluorophenol and 900 mg mono-tert-butyl piperidine-1,4-dicarboxylate are heated in 5 g polyphosphoric acid at 200° C. for 4 h. After cooling the reaction mixture is combined with ice water and made basic with 50% NaOH solution. The precipitate is suction filtered, washed with water and dried. 290 mg (V-8) are obtained as a solid.

Workup

  1. temperatureAfter cooling the reaction mixture
  2. filtrationfiltered
  3. washwashed with water
  4. customdried
  5. custom290 mg (V-8) are obtained as a solid

Sources & evidence

ORD record
ord-787dbb4a23a84bf5919e79528e967492
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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