HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-methoxy-N-(4-phenylpiperidin-4-ylmethyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Tert-butyl 4-[(2-methoxyacetylamino)-methyl]-4-phenylpiperidine-1-carboxylate | HCID 58080361 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-methoxy-N-(4-phenylpiperidin-4-ylmethyl)-acetamide | HCID 58080376 | — |
Reaction Steps
1 g tert-butyl 4-[(2-methoxyacetylamino)-methyl]-4-phenylpiperidine-1-carboxylate are placed in 4 ml dichloromethane. Then 1.7 ml trifluoroacetic acid are added and the mixture is stirred overnight at ambient temperature. The reaction mixture is made basic with potassium carbonate and the organic phase is evaporated to dryness. 610 mg (V-12) are obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754073B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-c0df48b1c63d43a9a8dee11db881786b |
| Source note | uspto-grants-2014_06 |