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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 405941Generated: October 30, 2026

Dimethyl trans-1,2-cyclopropanedicarboxylate → rac-tert-butyl N-((1R,2R)-2-aminocyclopropyl)carbamate

https://huagongshe.com/reaction/405941

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl trans-1,2-cyclopropanedicarboxylateHCID 6429599—
Reactantrac-tert-butyl N-[(1R,2R)-2-aminocyclopropyl]carbamate hydrochlorideHCID 57364724—
Productrac-tert-butyl N-((1R,2R)-2-aminocyclopropyl)carbamateHCID 33746924—

Reaction Steps

Starting from dimethyl trans-1,2-cyclopropanedicarboxylate, trans-N-tert-butyloxycarbonyl-1,2-cyclopropanediamin hydrochloride may be prepared and purified analogously to cis-N-tert-butyloxycarbonyl-1,2-cyclopropanediamin hydrochloride (see 58.4). M.p: 200-202° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08754073B2
Source datasetuspto-grants-2014_06
ORD IDord-117921532e5f4fddb34ec38de3ed4b42
Source noteuspto-grants-2014_06