β-amino-α-phenyl-Benzeneethanol → HCID 58080370, compound

HRID 405946Notes

Reaction equation

HRID 405946 reaction equation
[N:1]1([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5][CH:4]([C:7]([O-:9])=O)[CH2:3][CH2:2]1.[NH2:17][CH:18]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)O>>[C:27]1([C:18]2[N:17]=[C:7]([CH:4]3[CH2:3][CH2:2][N:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]3)[O:9][C:19]=2[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 22243β-amino-α-phenyl-BenzeneethanolHCID 6921829HCID 6921829, compound

Product 1

HCID 58080370HCID 58080370, compound

Procedure

Starting from 1.08 g mono-tert-butyl piperidine-1,4-dicarboxylate and 1 g 2-amino-1,2-diphenyl-ethanol the product may be obtained as described in the literature (see Tet. 2001, 4867). The product is purified by chromatography (method B). 560 mg are obtained as an oil. Analytical HPLC-MS (method A): RT=1.72 min.

Workup

  1. custommay be obtained
  2. customThe product is purified by chromatography (method B)
  3. custom560 mg are obtained as an oil

Sources & evidence

ORD record
ord-c22be4158f7643678b61e58e51fe0cdd
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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