Dimethylformamide → HCID 50915133, compound

Participants

Reaction Conditions

Reaction Steps

0.665 g (1.4 mmol) (5) and 0.6853 g (2.1 mmol) Cs2CO3 was suspended in 3.3 ml freshly distilled DMF. 0.140 ml (2.1 mmol) BrCH2Cl was added and the mixture was heated at 150° C. for 1.5 h. The heat source was removed and the mixture was allowed to cool to r.t. after which the mixture was filtered and separated with 100 ml EtOAc and 100 ml H2O. The water phase was extracted with 2×100 ml EtOAc. The pooled organic phases were washed with 150 ml brine, dried over Na2SO4, filtered and evaporated. Flash chromatography (Pet. ether:EtOAc, 1:4) gave 0.167 g (0.43 mmol, 31%) (6).

Provenance & Evidence