Acetic Acid → HCID 66831405, compound

Participants

Reaction Steps

A mixture of 2-(chloromethyl)-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one (8.310 g, 39.09 mmol), N-bromosuccinimide (8.055 g, 42.99 mmol), and acetic acid (110.3 mL) was stirred at rt. After 6 h, the mixture was poured into water (300 mL) and the resulting precipitate was collected by filtration, washed with water (400 mL), and dried to give 3-bromo-2-(chloromethyl)-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one as a brown solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 8.97 (1 H, td), 8.19 (1 H, ddd, J=9.9, 7.1, 2.9 Hz), 7.86-7.94 (1 H, m), 4.81 (2 H, s); Mass Spectrum (ESI) m/e=292.9 (M+1).

Provenance & Evidence