Water → HCID 178424182, compound

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Reaction Steps

A mixture of (6-methyl-4-oxo-3-o-tolyl-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl methanesulfonate (100 mg, 0.28 mmol), 9H-purine-6-thiol (51 mg, 1.2 eq) and K2CO3 (46 mg, 1.2 eq) in 2 mL DMF was stirred at rt overnight. Water was added and the resulting solid was washed with water and dried in the open air. 6-Methyl-3-(2-methylphenyl)-2-((9H-purin-6-ylsulfanyl)methyl)-4H-pyrido[1,2-a]-pyrimidin-4-one was obtained as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.49 (1 H, s), 8.47 (1 H, s), 8.40 (1 H, s), 7.68 (1 H, t, J=8.0 Hz), 7.43 (1 H, d, J=8.0 Hz), 7.23-7.19 (4 H, m), 6.95 (1 H, d, J=8.0 Hz), 4.45 (1 H, d, J=12.0 Hz), 4.29 (1 H, d, J=12.0 Hz), 2.90 (3 H, s), 2.10 (3 H, s); Mass Spectrum (ESI) m/e=415 (M+1).

Provenance & Evidence