Hydrochloric Acid → HCID 66831374, compound

Participants

Reaction Conditions

Reaction Steps

A heterogeneous mixture of the (3-bromo-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate (4.24 g, 1.0 equiv.), conc. HCl (8.0 equiv.) and 1,4-dioxane (39 mL) was heated with stirring at 70° C. for 3 h. LCMS showed the completion of reaction. The residue was diluted with water (100 mL) and treated with 28% ammonium hydroxide (10 mL) to pH 10. The precipitate was filtered, washed with water (200 mL) and dried under high vacuum to give 3-bromo-2-(hydroxylmethyl)-4H-pyrido[1,2-a]pyrimidin-4-one as tan solid. Used without further purification: 1HNMR (400 MHz, DMSO-d6): δ 8.96-8.98 (dd, 1H), 8.03-8.08 (m,1H), 7.74-7.76 (dd, 1H), 7.43-7.48 (m,1H), 5.3 (t,1H), 4.6 (d,2H).

Provenance & Evidence