Difluoromethylenedioxybenzylpiperazine → 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid pyridin-3-ylamide

HRID 40600Notes

Reaction equation

[F:1][C:2]1([F:18])[O:6][C:5]2[CH:7]=[CH:8][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:10][C:4]=2[O:3]1.C([O:23][C:24]([N:26]1CC[N:29]([CH2:32][C:33]2[CH:43]=CC3OC(F)(F)OC=3C=2)[CH2:28][CH2:27]1)=O)(C)(C)C>>[N:29]1[CH:32]=[CH:33][CH:43]=[C:27]([NH:26][C:24]([N:15]2[CH2:14][CH2:13][N:12]([CH2:11][C:9]3[CH:8]=[CH:7][C:5]4[O:6][C:2]([F:1])([F:18])[O:3][C:4]=4[CH:10]=3)[CH2:17][CH2:16]2)=[O:23])[CH:28]=1

Participants

Reactant 2

HCID 66553702Difluoromethylenedioxybenzylpiperazine

HCID 687038314-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 578808834-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid pyridin-3-ylamide

Procedure

1-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine. The title compound was prepared from 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester in analogy with Example 6.

Sources & evidence

ORD record: ord-d6b08272188347e8bf5f86e235643f0f
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08530476B2

Reaction notes

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