HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-nitrophenol → HCID 58421788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-nitrophenol | HCID 9937 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-Cyclohexen-1-OL | HCID 13198 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58421788 | HCID 58421788 | — |
Reaction Steps
1.89 ml DEAD were added to an ice-cooled solution of the 1.57 g 5-Fluoro-2-nitrophenol, 1.18 ml 2-cyclohexenol and 3.15 g triphenylphosphin in methylene chloride. The reaction mixture was stirred and allowed to warm to rt overnight. The solvent was removed in vacuo. Purification is achieved by silica gel column chromatography with iso-hexane/EtOAc (gradient: 100% i-hexane→10:1 i-hexane/EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754079B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-b58ae56b7e444246a825b6b9b9427c89 |
| Source note | uspto-grants-2014_06 |