HCID 67385069, compound → HCID 67390370, compound

HRID 406005Notes

Reaction equation

HRID 406005 reaction equation
[C:1]([Si:5]([O:8][C@H:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([O:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[N+:23]([O-])=O)[CH2:10]1)([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2]>[Ni].CO>[C:1]([Si:5]([CH3:7])([CH3:6])[O:8][C@H:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([O:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[NH2:23])[CH2:10]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 67385069HCID 67385069, compound

Product 1

HCID 67390370HCID 67390370, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 9.2 g racemic tert-Butyl-[trans-3-(5-fluoro-2-nitro-phenoxy)cyclohexyloxy]-dimethyl-silane and 0.92 g of Raney Nickel in 200 ml of methanol was hydrogenated at rt under 50 psi for 6 hours. The reaction mixture was filtered and the filtrate concentrated.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-debe68185dba4e539dfe2c35b49ffd03
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

Loading…