2,4-Difluoronitrobenzene → Carbamic acid, N-[3-(5-fluoro-2-nitrophenoxy)cyclohexyl]-N-methyl-, 1,1-dimethylethyl ester

HRID 406019Notes

Reaction equation

HRID 406019 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12]([O:16][C:17](=[O:27])[N:18]([CH:20]1[CH2:25][CH2:24][CH2:23][CH:22]([OH:26])[CH2:21]1)[CH3:19])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17](=[O:27])[N:18]([CH:20]1[CH2:25][CH2:24][CH2:23][CH:22]([O:26][C:2]2[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=2[N+:9]([O-:11])=[O:10])[CH2:21]1)[CH3:19])([CH3:15])([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 679672,4-DifluoronitrobenzeneHCID 58421494HCID 58421494, compound

Product 1

HCID 58421758Carbamic acid, N-[3-(5-fluoro-2-nitrophenoxy)cyclohexyl]-N-methyl-, 1,1-dimethylethyl ester

Procedure

Prepared analogously to III.1 from 81 μl 2,4-difluoronitrobenzene and 0.17 g (3-hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester.

Sources & evidence

ORD record
ord-66810898f038440c8f15e00cbe54b306
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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