HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbamic acid, 4-pyridinyl-, phenyl ester → 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid pyridin-4-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbamic acid, 4-pyridinyl-, phenyl ester | HCID 11401617 | — |
| Reactant | Difluoromethylenedioxybenzylpiperazine | HCID 66553702 | — |
| Product | 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid pyridin-4-ylamide | HCID 57880849 | — |
Reaction Steps
The title compound was prepared from pyridin-4-yl-carbamic acid phenyl ester and 1-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine in analogy with Example 142. 1H NMR (400 MHz, CDCl3): 8.36-8.34 (d, J=6.8 Hz, 2H), 7.41-7.39 (d, J=5.8 Hz, 2H), 7.10 (s, 1H), 6.99 (s, 2H), 3.55-3.53 (m, 4H), 3.49 (s, 2H), 2.47-2.44 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530476B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-bba7aaa71d4546efb90b45a1edc6d669 |
| Source note | uspto-grants-2013_09 |