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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40602Generated: October 26, 2026

Carbamic acid, 4-pyridinyl-, phenyl ester → 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid pyridin-4-ylamide

https://huagongshe.com/reaction/40602

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbamic acid, 4-pyridinyl-, phenyl esterHCID 11401617—
ReactantDifluoromethylenedioxybenzylpiperazineHCID 66553702—
Product4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid pyridin-4-ylamideHCID 57880849—

Reaction Steps

The title compound was prepared from pyridin-4-yl-carbamic acid phenyl ester and 1-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine in analogy with Example 142. 1H NMR (400 MHz, CDCl3): 8.36-8.34 (d, J=6.8 Hz, 2H), 7.41-7.39 (d, J=5.8 Hz, 2H), 7.10 (s, 1H), 6.99 (s, 2H), 3.55-3.53 (m, 4H), 3.49 (s, 2H), 2.47-2.44 (m, 4H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08530476B2
Source datasetuspto-grants-2013_09
ORD IDord-bba7aaa71d4546efb90b45a1edc6d669
Source noteuspto-grants-2013_09