HCID 58421737, compound → HCID 58421477, compound

HRID 406022Notes

Reaction equation

HRID 406022 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[C:4]([O:11][C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[O:18][CH3:19])[CH:3]=1.[H][H]>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([O:11][C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[O:18][CH3:19])[CH:3]=1

Participants

5

Reactant 2

HCID 58421737HCID 58421737, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58421477HCID 58421477, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(R,R)-4-fluoro-2-(2-methoxycyclohexyloxy)-nitrobenzene (0.18 g) in methanol (20.0 ml) was hydrogenated under 50 psi hydrogen for 20 h at rt using palladium on charcoal (5%) (40 mg) as catalyst. The catalyst was filtered off; the resulting solution was evaporated to dryness to yield an oil.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe resulting solution was evaporated to dryness
  3. customto yield an oil

Sources & evidence

ORD record
ord-340d41fd9b5d4fcdad7fb228c16a65e2
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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