HCID 178526678, compound → HCID 178507707, compound

HRID 406026Notes

Reaction equation

HRID 406026 reaction equation
[N+:1]([C:4]1[C:5]([O:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([OH:17])[CH2:13][CH2:12]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>[Ni].CO>[NH2:1][C:4]1[C:5]([O:10][C@H:11]2[CH2:12][CH2:13][C@H:14]([OH:17])[CH2:15][CH2:16]2)=[N:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 178526678HCID 178526678, compound

Product 1

HCID 178507707HCID 178507707, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 0.29 g trans-4-(3-nitro-pyridin-2-yloxy)-cyclohexanol and 0.05 g Raney nickel in 50 ml methanol was hydrogenated at 5 bar and rt for 4.5 hours. The reaction mixture was filtered and the filtrate concentrated.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-0047a51bdcc6427aa64e2ba407e8a899
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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