HCID 178418361, compound → HCID 178507658, compound

HRID 406028Notes

Reaction equation

HRID 406028 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[C:4]([O:11][C@H:12]2[CH2:17][CH2:16][C@@H:15]([OH:18])[CH2:14][CH2:13]2)[CH:3]=1.[H][H]>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([O:11][C@H:12]2[CH2:13][CH2:14][C@@H:15]([OH:18])[CH2:16][CH2:17]2)[CH:3]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178526646HCID 178526646, compound

Product 1

HCID 178507658HCID 178507658, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-Fluoro-2-(cis-4-hydroxycyclohexyloxy)-nitrobenzene (2.00 g) in methanol (15.0 ml) was hydrogenated under 50 psi hydrogen using palladium on charcoal (5%) as catalyst (300 mg) at RT for 2 h. The catalyst was filtered off; the solvent was removed in vacuo to yield the desired product as 95% pure oil.

Workup

  1. customat RT
  2. customfor 2 h
  3. filtrationThe catalyst was filtered off
  4. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-902a9179711943a9affbbf69385e3586
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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