Phenyl pyrimidin-4-ylcarbamate → 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid pyrimidin-4-ylamide

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Reaction Steps

The title compound was prepared from pyrimidin-4-yl-carbamic acid phenyl ester and 1-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine in analogy with Example 142. 1H NMR (400 MHz, CDCl3): 8.76 (s, 1H), 8.54 (d, J=6.1 Hz, 1H), 7.97 (d, J=5.3 Hz, 1H), 7.65-7.39 (m, 2H), 7.19-7.01 (m, 2H), 4.03-3.55 (m, 6H), 2.91-2.49 (m, 4H).

Provenance & Evidence