反应详情

温度

0 °C

AD-mix-alpha (7.57 g) was added to t-butanol (20.0 ml) and water (25.0 ml) and stirred for 10 min. The mixture was cooled to 0° C. and 2-(cyclopent-2-enyloxy)-4-fluoro-1-nitrobenzene (1.21 g) was added. After stirring at room temperature overnight the mixture was recooled at 0° C. and sodium metabisulfite (8.13 g) was added. After 10 min the reaction mixture was stirred at room temperature for 1 h and extracted with EtOAc. The combined organic extracts were washed with brine passed through a hydrophobic frit and concentrated in vacuo to yield the desired product.

1. stirringAfter stirring at room temperature overnight the mixture
2. customwas recooled at 0° C.
3. stirringAfter 10 min the reaction mixture was stirred at room temperature for 1 h
4. extractionextracted with EtOAc
5. washThe combined organic extracts were washed with brine
6. concentrationconcentrated in vacuo