HCID 67389932, compound → HCID 67389889, compound

HRID 406057Notes

Reaction equation

HRID 406057 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:18]([O-])=O)=[C:6]([CH:17]=1)[O:7][C@H:8]1[CH2:12][CH2:11][C@H:10]([NH:13][C:14](=[O:16])[CH3:15])[CH2:9]1>CO.[Ni]>[NH2:18][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:17][C:6]=1[O:7][C@H:8]1[CH2:12][CH2:11][C@H:10]([NH:13][C:14](=[O:16])[CH3:15])[CH2:9]1

Participants

4

Reactant 1

HCID 67389932HCID 67389932, compound

Product 1

HCID 67389889HCID 67389889, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of N-[(1S,3S)-3-(5-fluoro-2-nitro-phenoxy)-cyclopentyl]-acetamide (1.45 g) and Raney Ni (200 mg) in MeOH (150 ml) was stirred at rt overnight under hydrogen atmosphere (5 bar). The catalyst was removed by filtration and the filtrate was concentrated to give the desired product.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-96284c58d92347f3918d652b0df90402
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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