HCID 22591436, compound → HCID 20754681, compound

HRID 406058Notes

Reaction equation

HRID 406058 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:20]([N+:21]([O-])=O)=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]>[Ni].CO>[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[C:20]([NH2:21])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:12][CH2:13]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 22591436HCID 22591436, compound

Product 1

HCID 20754681HCID 20754681, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 7.8 g [4-(3-nitro-pyridin-2-yloxy)cyclohexyl]-carbamic acid tert-butyl ester and 0.8 g raney nickel in 100 ml methanol was hydrogenated at rt under 50 psi overnight. The reaction mixture was filtered and the filtrate concentrated.

Workup

  1. customwas hydrogenated at rt under 50 psi overnight
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-601c8add062c40398a68d463ba4f42c0
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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