HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 406059Generated: October 30, 2026
2,4-Difluoronitrobenzene → HCID 58421532, compound
https://huagongshe.com/reaction/406059
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,4-Difluoronitrobenzene | HCID 67967 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Reactant | tert-Butyl [(1S,2S)-2-hydroxycyclopentyl]carbamate | HCID 10104271 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58421532 | HCID 58421532 | — |
Reaction Steps
(1S,2S)-trans-N-boc-2-aminocyclopentanol was dissolved in 50 ml THF and cooled to 10° C. To the reaction mixture were added 32.2 ml LiHMDS 1M in THF. After 1 hour 2.72 ml 2,4-difluoronitrobenzol were added and the mixture was stirred at rt overnight. Then the mixture was poured in water and extracted with ethylacetate. The organic layer was washed with water, dried and concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08754079B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-12a2ae7edcfd47aeb5df371811bec19e |
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| Source note | uspto-grants-2014_06 |
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