N,N-Dimethyl-1,3-propanediamine → HCID 178474850, compound

HRID 406062Notes

Reaction equation

HRID 406062 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19](O)=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][C@H:26]([N:29]([CH3:33])[C:30](=[O:32])[CH3:31])[CH2:25][CH2:24]2)[CH:3]=1.[CH3:34][N:35]([CH3:40])[CH2:36][CH2:37][CH2:38][NH2:39]>>[CH3:34][N:35]([CH3:40])[CH2:36][CH2:37][CH2:38][NH:39][C:19]([C:16]1[S:15][C:11]2[N:12]=[CH:13][N:14]=[C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[O:22][C@H:23]3[CH2:28][CH2:27][C@H:26]([N:29]([CH3:33])[C:30](=[O:32])[CH3:31])[CH2:25][CH2:24]3)[C:10]=2[C:17]=1[CH3:18])=[O:20]

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 178474851HCID 178474851, compound

Product 1

HCID 178474850HCID 178474850, compound

Procedure

Prepared analogously to 1.4 from 0.094 g 4-(4-Fluoro-2-(trans-4-(N-methylacetamido)cyclohexyloxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (cpd.7.2) and 3-(dimethylamino)propylamine (126 μl).

Sources & evidence

ORD record
ord-0ff599fd1623477a8fd624013f2096a6
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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