N,N-Dimethyl-1,3-propanediamine → HCID 58421705, compound

HRID 406069Notes

Reaction equation

HRID 406069 reaction equation
[CH3:1][C:2]1([CH3:30])[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[NH:16][C:17]2[C:18]3[C:25]([CH3:26])=[C:24]([C:27]([OH:29])=O)[S:23][C:19]=3[N:20]=[CH:21][N:22]=2)[CH2:4][CH2:3]1.[CH3:31][N:32]([CH3:37])[CH2:33][CH2:34][CH2:35][NH2:36]>>[CH3:31][N:32]([CH3:37])[CH2:33][CH2:34][CH2:35][NH:36][C:27]([C:24]1[S:23][C:19]2[N:20]=[CH:21][N:22]=[C:17]([NH:16][C:10]3[CH:11]=[CH:12][C:13]([F:15])=[CH:14][C:9]=3[O:8][CH:5]3[CH2:6][CH2:7][C:2]([CH3:30])([CH3:1])[CH2:3][CH2:4]3)[C:18]=2[C:25]=1[CH3:26])=[O:29]

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 58421775HCID 58421775, compound

Product 1

HCID 58421705HCID 58421705, compound

Procedure

Prepared analogously to 29.3 from 0.150 g 4-[2-(4,4-dimethyl-cyclohexyloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (cpd. 31.2) and 0.044 ml N,N-dimethyl-propane-1,3-diamine.

Sources & evidence

ORD record
ord-26202dff7d1940c78f39c501020bdc93
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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