Ammonia → HCID 67390263, compound

HRID 406081Notes

Reaction equation

HRID 406081 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19](O)=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][CH2:26][C@H:25]([OH:29])[CH2:24]2)[CH:3]=1.[NH3:30]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([NH2:30])=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][CH2:26][C@H:25]([OH:29])[CH2:24]2)[CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 67389568HCID 67389568, compound

Product 1

HCID 67390263HCID 67390263, compound

Procedure

Prepared analogously to example 1.4 from 5.6 g racemic racemic 4-[4-Fluoro-2-((trans)-3-hydroxy-cyclohexyloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and 100 ml ammonia (0.5 M in THF).

Sources & evidence

ORD record
ord-2c705fc1bd444b6aad34aa5b208e432b
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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