Ammonia → HCID 67391723, compound

HRID 406083Notes

Reaction equation

HRID 406083 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([OH:21])=O)[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][CH2:26][C@@H:25]([O:29][CH3:30])[CH2:24]2)[CH:3]=1.[NH3:31]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([NH2:31])=[O:21])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][CH2:26][C@@H:25]([O:29][CH3:30])[CH2:24]2)[CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 67389242HCID 67389242, compound

Product 1

HCID 67391723HCID 67391723, compound

Procedure

Prepared analogously to example 1.4 from 0.3 g racemic 4-[4-Fluoro-2-((cis)-3-methoxy-cyclohexyloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and ammonia (0.5 M in dioxan).

Sources & evidence

ORD record
ord-60d8eefb831d4ea0aec8bd39594db59f
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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