Ammonia → HCID 178496621, compound

HRID 406088Notes

Reaction equation

HRID 406088 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19](O)=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][C@H:26]([O:29][CH3:30])[CH2:25][CH2:24]2)[CH:3]=1.[NH3:31]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([NH2:31])=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][C@H:26]([O:29][CH3:30])[CH2:25][CH2:24]2)[CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178496626HCID 178496626, compound

Product 1

HCID 178496621HCID 178496621, compound

Procedure

Prepared analogously to 1.4 from 0.1 g 4-[4-fluoro-2-(trans-4-methoxycyclohexyloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and ammonia (7M in methanol).

Sources & evidence

ORD record
ord-e2227412c65b4692b5c484f875cf1577
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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