N,N-Dimethyl-1,3-propanediamine → HCID 178496623, compound

HRID 406090Notes

Reaction equation

HRID 406090 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([OH:21])=O)[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][C@@H:26]([O:29][CH3:30])[CH2:25][CH2:24]2)[CH:3]=1.[CH3:31][N:32]([CH3:37])[CH2:33][CH2:34][CH2:35][NH2:36]>>[CH3:31][N:32]([CH3:37])[CH2:33][CH2:34][CH2:35][NH:36][C:19]([C:16]1[S:15][C:11]2[N:12]=[CH:13][N:14]=[C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[O:22][C@H:23]3[CH2:28][CH2:27][C@@H:26]([O:29][CH3:30])[CH2:25][CH2:24]3)[C:10]=2[C:17]=1[CH3:18])=[O:21]

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 178496625HCID 178496625, compound

Product 1

HCID 178496623HCID 178496623, compound

Procedure

Prepared analogously to 1.4 from 0.1 g 4-[4-fluoro-2-(cis-4-methoxy-cyclohexyloxy)phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and 42 μl N,N-dimethyl-1,3-propanediamine.

Sources & evidence

ORD record
ord-e9ed0be2095a415a932fc76c512dfc50
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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