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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 406096Generated: October 30, 2026

Ammonia → HCID 178496628, compound

https://huagongshe.com/reaction/406096

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniaHCID 222—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
ReactantHCID 178496629HCID 178496629—
SolventDimethylformamideHCID 6228—
ProductHCID 178496628HCID 178496628—

Reaction Steps

Prepared analogously to 1.4 from 0.005 g 4-[2-(trans-4-methoxy-cyclohexyloxy)pyridin-3-ylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and ammonia (0.5 M in THF) in DMF using TBTU instead of HATU.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08754079B2
Source datasetuspto-grants-2014_06
ORD IDord-89dfb3452d4a4c76b027a420775bb8a8
Source noteuspto-grants-2014_06