Ammonia → HCID 58421581, compound

HRID 406105Notes

Reaction equation

HRID 406105 reaction equation
[CH:1]1([O:5][C:6]2[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=2[NH:13][C:14]2[C:15]3[C:22]([CH3:23])=[C:21]([C:24]([OH:26])=O)[S:20][C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:4][CH2:3][CH2:2]1.[NH3:27]>CO>[CH:1]1([O:5][C:6]2[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=2[NH:13][C:14]2[C:15]3[C:22]([CH3:23])=[C:21]([C:24]([NH2:27])=[O:26])[S:20][C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58421589HCID 58421589, compound

Product 1

HCID 58421581HCID 58421581, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to example 1.4 from 4-(2-cyclobutoxy-4-fluoro-phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (127 mg) and 7 M ammonia in MeOH (1 ml).

Sources & evidence

ORD record
ord-460b15d7a12e4552ae76edead7fcf002
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

Loading…