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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 406106Generated: October 25, 2026

Bromocyclopentane → 4-(2-Cyclopentoxy-4-fluoro-phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

https://huagongshe.com/reaction/406106

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromocyclopentaneHCID 8728—
ReactantMethyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylateHCID 58413076—
Product4-(2-Cyclopentoxy-4-fluoro-phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl esterHCID 58421753—

Reaction Steps

Prepared analogously to example 243.2 from 4-(4-fluoro-2-hydroxy-phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (67 mg) and bromocyclopentane (60 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08754079B2
Source datasetuspto-grants-2014_06
ORD IDord-5e9e7a510b4f40a8a72188daadffd5bf
Source noteuspto-grants-2014_06