Ammonia → HCID 58421505, compound

HRID 406107Notes

Reaction equation

HRID 406107 reaction equation
[CH:1]1([O:6][C:7]2[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=2[NH:14][C:15]2[C:16]3[C:23]([CH3:24])=[C:22]([C:25](O)=[O:26])[S:21][C:17]=3[N:18]=[CH:19][N:20]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:28]>CO>[CH:1]1([O:6][C:7]2[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=2[NH:14][C:15]2[C:16]3[C:23]([CH3:24])=[C:22]([C:25]([NH2:28])=[O:26])[S:21][C:17]=3[N:18]=[CH:19][N:20]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58421782HCID 58421782, compound

Product 1

HCID 58421505HCID 58421505, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to example 1.4 from 4-(2-cyclopentoxy-4-fluoro-phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (59 mg) and 7 M ammonia in MeOH (0.5 ml).

Sources & evidence

ORD record
ord-d3dec03f9b624f69a316de24c47a1581
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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