(4-Aminobut-2-yn-1-yl)dimethylamine → HCID 178475045, compound

HRID 406108Notes

Reaction equation

HRID 406108 reaction equation
[C:1]([NH:4][C@H:5]1[CH2:8][C@H:7]([O:9][C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[NH:17][C:18]2[C:19]3[C:26]([CH3:27])=[C:25]([C:28]([OH:30])=O)[S:24][C:20]=3[N:21]=[CH:22][N:23]=2)[CH2:6]1)(=[O:3])[CH3:2].[CH3:31][N:32]([CH3:38])[CH2:33][C:34]#[C:35][CH2:36][NH2:37]>>[CH3:31][N:32]([CH3:38])[CH2:33][C:34]#[C:35][CH2:36][NH:37][C:28]([C:25]1[S:24][C:20]2[N:21]=[CH:22][N:23]=[C:18]([NH:17][C:11]3[CH:12]=[CH:13][C:14]([F:16])=[CH:15][C:10]=3[O:9][C@H:7]3[CH2:8][C@H:5]([NH:4][C:1](=[O:3])[CH3:2])[CH2:6]3)[C:19]=2[C:26]=1[CH3:27])=[O:30]

Participants

3

Reactant 2

HCID 12259565(4-Aminobut-2-yn-1-yl)dimethylamineHCID 178475046HCID 178475046, compound

Product 1

HCID 178475045HCID 178475045, compound

Procedure

Prepared analogously to 35.3 from 0.080 g 4-[2-(trans-3-acetylamino-cyclobutoxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (cpd. 35.2) and 0.045 g 4-(dimethylamino)-but-2-ynylamin*2HCl.

Sources & evidence

ORD record
ord-3af1742999fe47cfac08af2db89a0b7f
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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