rac-tert-butyl N-[(1R,2R)-2-aminocyclopropyl]carbamate hydrochloride → HCID 178475044, compound

HRID 406109Notes

Reaction equation

HRID 406109 reaction equation
[C:1]([NH:4][C@H:5]1[CH2:8][C@H:7]([O:9][C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[NH:17][C:18]2[C:19]3[C:26]([CH3:27])=[C:25]([C:28](O)=[O:29])[S:24][C:20]=3[N:21]=[CH:22][N:23]=2)[CH2:6]1)(=[O:3])[CH3:2].Cl.[NH2:32][C@@H:33]1[CH2:35][C@H:34]1[NH:36][C:37](=[O:43])[O:38][C:39]([CH3:42])([CH3:41])[CH3:40]>>[C:39]([O:38][C:37](=[O:43])[NH:36][CH:34]1[CH2:35][CH:33]1[NH:32][C:28]([C:25]1[S:24][C:20]2[N:21]=[CH:22][N:23]=[C:18]([NH:17][C:11]3[CH:12]=[CH:13][C:14]([F:16])=[CH:15][C:10]=3[O:9][C@H:7]3[CH2:6][C@H:5]([NH:4][C:1](=[O:3])[CH3:2])[CH2:8]3)[C:19]=2[C:26]=1[CH3:27])=[O:29])([CH3:40])([CH3:42])[CH3:41]

Participants

3

Reactant 2

HCID 57364724rac-tert-butyl N-[(1R,2R)-2-aminocyclopropyl]carbamate hydrochlorideHCID 178475046HCID 178475046, compound

Product 1

HCID 178475044HCID 178475044, compound

Procedure

Prepared analogously to 35.3 from 0.080 g 4-[2-(trans-3-acetylamino-cyclobutoxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (cpd. 35.2) and 0.050 g tert-butyl (1R,2R)-2-aminocyclopropylcarbamate hydrochloride.

Sources & evidence

ORD record
ord-c33c1162f1674667947dc9dce3cdce20
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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