1-(3-Aminopropyl)-2-pyrrolidinone → HCID 178429335, compound

HRID 406114Notes

Reaction equation

HRID 406114 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([OH:21])=O)[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:28][CH2:27][C@H:26]([OH:29])[CH2:25][CH2:24]2)[CH:3]=1.[NH2:30][CH2:31][CH2:32][CH2:33][N:34]1[CH2:38][CH2:37][CH2:36][C:35]1=[O:39]>>[O:39]=[C:35]1[CH2:36][CH2:37][CH2:38][N:34]1[CH2:33][CH2:32][CH2:31][NH:30][C:19]([C:16]1[S:15][C:11]2[N:12]=[CH:13][N:14]=[C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[O:22][C@H:23]3[CH2:24][CH2:25][C@H:26]([OH:29])[CH2:27][CH2:28]3)[C:10]=2[C:17]=1[CH3:18])=[O:21]

Participants

3

Reactant 2

HCID 821111-(3-Aminopropyl)-2-pyrrolidinoneHCID 178429620HCID 178429620, compound

Product 1

HCID 178429335HCID 178429335, compound

Procedure

Prepared analogously to 1.4 from 0.042 g 4-[4-fluoro-2-(trans-4-hydroxycyclohexyloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and 0.015 g 1-(3-aminopropyl)-2-pyrrolidinone. The residue was purified by chromatography.

Workup

  1. customThe residue was purified by chromatography

Sources & evidence

ORD record
ord-635d0baa73594621bbbd1b17d3951ad5
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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