Hydrochloric Acid → HCID 71280830, compound

Participants

Reaction Steps

4-{2-[4-((2S,3′S)-2-Methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenyl]-acetylamino}-piperidine-1-carboxylic acid tert-butyl ester (2.92 g, 6.2 mmol) was dissolved in 5 mL of dioxane. To this solution was added 1.0 g of PhSH, followed by addition of 4N HCl in dioxane (6.2 mL, 24.8 mmol, 4 equiv.). The solution was stirred at rt overnight. HCl was removed by passing N2 through the solution which was absorbed by NaOH aq solution. The solvent was removed by reduced pressure distillation. The residue was further dried under high vacuum to get 2.7 g (100%) of the title compound as a powder.

Provenance & Evidence