4-Methylbenzaldehyde → 4-[(4-methylphenyl)methyl]-N-phenylpiperazine-1-carboxamide

HRID 40616Notes

Reaction equation

[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1>>[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:24]=[CH:23][C:20]([CH3:21])=[CH:19][CH:18]=3)[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 77254-Methylbenzaldehyde

HCID 7015289N-phenylpiperazine-1-carboxamide

Product 1

HCID 64696564-[(4-methylphenyl)methyl]-N-phenylpiperazine-1-carboxamide

Procedure

The title compound was prepared from piperazine-1-carboxylic acid phenylamide and 4-methylbenzaldehyde. 1H NMR (400 MHz, CDCl3): 7.35-7.00 (m, 9H), 6.32 (s, 1H), 3.50-3.48 (m, 6H), 2.49-2.46 (m, 4H), 2.35 (s, 3H).

Sources & evidence

ORD record: ord-2d7fc4a00bb74c82804ddd364e7e0bdc
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08530476B2

Reaction notes

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