Hydrochloric Acid → HCID 178479288, compound

Participants

Reaction Steps

To 1,1-dimethylethyl {cis-3-[(2,3-dichlorophenyl)oxy]cyclobutyl}carbamate (5.21 g, 15.68 mmol) was added hydrochloric acid in dioxane (4M, 40 mL, 160 mmol) and the reaction mixture stirred in a sealed vessel at room temperature for 1 hour. The mixture was diluted with dioxane (300 mL) and stirred for a further 5 hours. Diethyl ether (300 mL) was then added and the solid collected by filtration and dried under high vacuum overnight to give the title compound (4.149 g)

Provenance & Evidence