Hydrochloric Acid → HCID 178479290, compound

Participants

Reaction Steps

To a stirred solution of 1,1-dimethylethyl(trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}cyclobutyl)carbamate (3.16 g, 9.05 mmol) in 1,4-dioxane (20 mL) was added hydrochloric acid in 1,4-dioxane (4M, 25 mL, 100 mmol) in one charge. The reaction vessel was sealed and the reaction stirred at ambient temperature for 16 hours. The majority of the solvent was then removed in vacuo leaving a slurry which was diluted with diethyl ether (ca 50 mL) and the solid collected by filtration and dried in vacuo to give the title compound (2.187 g).

Provenance & Evidence