1,4-Dioxane → HCID 178505899, compound

Participants

Reaction Steps

1,1-Dimethylethyl(trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}cyclobutyl)(imidazo[1,2-a]pyridin-8-ylmethyl)carbamate (62 mg, 0.129 mmol) was stirred in 4M HCl in dioxane (5 mL, 20 mmol) for 3 hours when LCMS indicated the reaction to be complete. The mixture was loaded onto a SCX cartridge (2 g) and eluted with MeOH (3 column volumes) and flushed with ammonia in MeOH. The eluant was concentrated in vacuo to give slightly impure product which was dissolved in 50:50 DMSO/MeOH (1 mL) and purified by MDAP to give the title compound (16.8 mg).

Provenance & Evidence