Imidazo(1,2-a)pyridine-8-carbaldehyde → HCID 178441230, compound

HRID 406296Notes

Reaction equation

HRID 406296 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]=O)[C:5]=12.Cl.[CH3:13][C:14]([C:17]1[C:22]([F:23])=[CH:21][C:20]([O:24][C@@H:25]2[CH2:28][C@H:27]([NH2:29])[CH2:26]2)=[CH:19][C:18]=1[F:30])([CH3:16])[CH3:15]>>[CH3:16][C:14]([C:17]1[C:18]([F:30])=[CH:19][C:20]([O:24][C@@H:25]2[CH2:26][C@H:27]([NH:29][CH2:10][C:6]3[C:5]4[N:4]([CH:3]=[CH:2][N:1]=4)[CH:9]=[CH:8][CH:7]=3)[CH2:28]2)=[CH:21][C:22]=1[F:23])([CH3:13])[CH3:15]

Participants

3

Reactant 2

HCID 10997174Imidazo(1,2-a)pyridine-8-carbaldehydeHCID 178441229HCID 178441229, compound

Product 1

HCID 178441230HCID 178441230, compound

Procedure

Prepared similarly to Example 1 from imidazo[1,2-a]pyridine-8-carbaldehyde and cis-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}cyclobutanamine hydrochloride. LCMS (System B): tRET=3.28 min; MH+ 386

Workup

  1. custom=3.28 min

Sources & evidence

ORD record
ord-96698d167ee54f829e2da396170f2867
Source dataset
uspto-grants-2014_06
Patent number
US08754101B2

Reaction notes

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