Maleic Acid → HCID 178505900, compound

HRID 406299Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C@@H:9]2[CH2:12][C@H:11]([N:13]([CH2:21][C:22]3[C:23]4[N:24]([CH:28]=[CH:29][N:30]=4)[CH:25]=[CH:26][CH:27]=3)C(=O)OC(C)(C)C)[CH2:10]2)=[CH:4][C:3]=1[C:31]([F:34])([F:33])[F:32].[C:35]([OH:42])(=[O:41])/[CH:36]=[CH:37]\[C:38]([OH:40])=[O:39]>>[C:35]([OH:42])(=[O:41])/[CH:36]=[CH:37]\[C:38]([OH:40])=[O:39].[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C@@H:9]2[CH2:12][C@H:11]([NH:13][CH2:21][C:22]3[C:23]4[N:24]([CH:28]=[CH:29][N:30]=4)[CH:25]=[CH:26][CH:27]=3)[CH2:10]2)=[CH:4][C:3]=1[C:31]([F:33])([F:32])[F:34]

Participants

Reactant 2

HCID 444266Maleic Acid

HCID 178453071HCID 178453071, compound

Product 1

HCID 178505900HCID 178505900, compound

Procedure

Prepared similarly to Example 16 by acidic deprotection of 1,1-dimethylethyl (cis-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}cyclobutyl)(imidazo[1,2-a]pyridin-8-ylmethyl)carbamate followed by conversion of the product into the maleate salt with maleic acid.

Sources & evidence

ORD record: ord-1caa31155c6d41e8903454b5ce85c2f5
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08754101B2

Reaction notes

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